CareLit Fachartikel
Cell killing and gene transfer by parvovirus H1 and derived vector in human HCC cells that lack P53
M Möhler, M Zeidler, S Küster, PR Galle, J Rommelaere, J Cornelis · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1131268
CareLit-ID
Jahr
2004
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Zusammenfassung
Mutations in the tumor suppressor p53 are a common event in human heptocellular carcinoma (HCC). Abrogations of p53 function lead to more aggressive cancer phenotypes and worse clinical outcome. Thus, a major goal of molecular oncology is to identify means to kill cells lacking p53. Autonomous parvoviruses preferentially replicate in and kill transformed cells and reduce the incidence of spontaneous and implanted tumors in animals. Because of these oncotropic and oncolytic properties parvoviruses deserve to be considered as antitumor vectors. Methods: We explored the role of p53 in regulating cell killing and ge…
Schlagworte
hepatocellular carcinoma
p53
parvovirus
Apoptosis
Chimera
Lead
After
Tumor
Zeitschrift für Gastroenterologie
