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Up-regulation of nNOS and associated increase in vasorelaxation in superior mesenteric arteries in portal hypertension

L Jurzik, R Wiest, RH Straub, J Schoelmerich · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1131269
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
L Jurzik, R Wiest, RH Straub, J Schoelmerich
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816118

Zusammenfassung

Splanchnic arterial vasodilatation is the pathophysiological hallmark in the development of the hyperdynamic circulation in portal hypertension. This has been attributed largely to vascular NO overproduction. Three NO-synthase-(NOS)-isoforms have been identified of which e(ndothelial)-NOS has been found up-regulated and I(nducible)-NOS not expressed in the splanchnic circulation in portal hypertension. N(euronal)-NOS so far has not been investigated and hence, the current study evaluates in a model of portal vein-ligated rats (PVL) nNOS-expression and nNOS-mediated vasorelaxation. Methods: Mesenteric vasculature…

Schlagworte

portal hypertension nitric oxide animal vasodilation Mesenteric Arteries Arteries Adventitia After Zeitschrift für Gastroenterologie