CareLit Fachartikel
Hepatocellular STAT activation via the receptor gp130 leads to liver protection in T-cell mediated hepatitis– IL6/gp130 signalling in liver protection
C Klein, T Wüstefeld, S Rose-John, MP Manns, C Trautwein · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1131273
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
The IL6/gp130 signalling in hepatocytes is protective in ConA hepatitis. To determine the cellular transducers in the IL6/gp130 dependend liver protection we generated mice with hepatocyte specific deletions for gp130 STAT or RAS signalling to differentiate the IL6/gp130 downstream cascades in this model. For the functional characterisation of these new transgenic mice, we isolated primary hepatocytes from ΔSTAT and ΔRAS mice, stimulated them with IL6 and analyzed the gp130 dependend STAT activation and the RAS/MAPK signalling. No STAT activation was observed in ΔSTAT primary hepatocytes after IL6, however ERK p…
Schlagworte
RASsignalling
STATsignalling
gp130
After
Hepatitis
Zeitschrift für Gastroenterologie
