CareLit Fachartikel

Effect of ethanol on the motility of the sphincter of Oddi

R Sári, A Pálvölgyi, Z Rakonczay, T Takács, A Szabolcs, J Lonovics, P Hegyi · Zeitschrift für Gastroenterologie · 2004 · Heft 05

Dokument
1131568
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Sári, A Pálvölgyi, Z Rakonczay, T Takács, A Szabolcs, J Lonovics, P Hegyi
Ausgabe
Heft 05 / 2004
Seiten
–
Erschienen: 2004-05-19 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-827028

Zusammenfassung

Background: The role of the sphincter of Oddi (SO) in ethanol (ETOH)-induced pancreatitis is controversial. Our aim was to characterise the effect of ETOH on basal and stimulated rabbit SO motility. Methods: SOs removed from white rabbits were placed in an organ bath containing Krebs solution. The effects of 0.2, 0.4, 0.6 and 0.8% of ETOH on the contractile responses of the SO were determined. The SOs were stimulated with either 0.1µM carbachol (C), 1µM erythromycin (E) or 0.1µM CCK. Results: (1) ETOH at a dose of 0.4% significantly decreased the baseline contractile amplitude from 11.98±0.05 mN to 11.19±0.07 mN…

Schlagworte

Carbachol Krebs Zeitschrift für Gastroenterologie