CareLit Fachartikel
p53 sequence determination in gastric biopsy specimens by chip and conventional sequencing technology
D Szőke, A Patócs, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Dokument
1131571
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Jahr
2004
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Zusammenfassung
Background: The mutation of p53 gene is play an important role in the pathogenesis of malignant diseases. Aims: To find disease specific p53 gene mutations and to compare the traditional sequencing technique with DNA sequencing microarray technology and to compare the mutations in the blood cells and in the pathological tissues. Materials and methods: After informed consent, peripheral blood was drawn and gastric biopsy samples were taken from the pathological and healthy part of the stomach. Genomic DNA was extracted from 25 biopsy and blood samples from patients with intestinal metaplasia. From the 11 exons of…
Schlagworte
Blood
Biopsy
Blood Cells
Diagnosis
After
Zeitschrift für Gastroenterologie
