Diagnosis of malignancy and benign alterations in gastric biopsy specimen by MRNA expression profiling
O Galamb, F Sipos, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The diagnosis of gastric biopsy specimen today is made by histologists and is based on morphological analysis of tissue sections. Aim: To develop disease specific and low cost mRNA expression arrays, and analysis technology which can contribute to the application of these techniques as a routine procedure. Materials and methods: After informed consent, gastric biopsy samples were taken from the pathological and healthy part of the stomach. Total RNA was extracted from the biopsies from 11 patients with gastric ulcer (6 H. pylori+), 5 with gastric cancer (1 H. pylori+) and 10 with atrophic gastritis (…