CareLit Fachartikel
Gli1 expression in rhabdomyosarcoma cells
M Vockerodt, J Wilting, L Schweigerer · Klinische Pädiatrie · 2004 · Heft 05
Dokument
1131712
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Sonic hedghog (Shh) singaling plays a critical role in organ development and its deregulation is associated with several tumors. Mutations or deletions of the Shh receptor Patched result in a constitutive activation of downstream signaling molecules, namely smoothened and the transcription factor Gli1. Mice with genetic alterations in the Shh pathway develop medulloblastoma and rhabdomyosracoma (RMS), indicating an important role of this pathway for the pathogenesis of RMS. We report here that expression of the protooncogen Gli1 correlates with the alveolar subtype of human rhabdomyosarcoma (RMS) cell lines. Gli…
Schlagworte
Expression
Cells
Activation
Rhabdomyosarcoma
Patched
Smoothened
Pathway
Alveolar
Sonic
Hedghog
Singaling
Plays
Klinische Pädiatrie
