CareLit Fachartikel
Different biological responses to chemotherapy of colon cancer may result in a similar clinical response
M Bhonde, ML Hanski, M Notter, M Zeitz, C Hanski · Zeitschrift für Gastroenterologie · 2004 · Heft 08
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1131862
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2004
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Zusammenfassung
Introduction: Irinotecan in combination with 5-FU is used as a „first line„ therapy for advanced colorectal cancer. We showed recently that the response to irinotecan in vitro is dependent on the p53 mutation status of the tumor: the p53wt colorectal cancer cell lines respond to treatment with a long-term arrest, the p53mut cells with a short term arrest followed by mitotic catastrophe and apoptosis. We investigated if the observed biological responses occur also in vivo and how they are reflected by the clinical response. Methods: Selected cell lines with a known p53 status (HCT116 and LS174T versus HCT116p53 k…
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Tumor
After
Apoptosis
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Zeitschrift für Gastroenterologie
