CareLit Fachartikel
Molecular, biochemical, ultrastructural and functional evidence of tight junction formation in normal and neoplastic human neuroendocrine cells
UF Pape, L Langbein, S Prätzel, WW Franke · Zeitschrift für Gastroenterologie · 2004 · Heft 08
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1131864
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Jahr
2004
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Zusammenfassung
Tight junctions (TJ) provide important features for intestinal epithelial integrity by establishing a paracellular barrier for solute transport and by providing a molecular fence for apico-basolateral polarity of cell membranes. However, little is known about TJ-formation and function of neuroendocrine (NE) cells of the diffuse endocrine system of the gastroenteropancreatic tract and tumors (NET) derived therefrom. We therefore studied TJ-molecules in NE cell lines QGP–1 and BON, normal human intestinal epithelia and NET. We found both TJ-transmembrane proteins (occludin, claudins–1,–3,–4,–7, JAM–1) and TJ-plaqu…
Schlagworte
barrier
cingulin
claudin
neuroendocrine tumor
occludin
tight junction
Claudins
Dextrans
Tumor
Chromogranin A
Zeitschrift für Gastroenterologie
