CareLit Fachartikel
Identification of NASH Quantitative Trait Loci (QTLs) using in silico mapping analysis in inbred mice
F Lammert, S Hillebrandt, S Matern, K Spatz, RM Green · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
1131870
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Non-alcoholic steatohepatitis (NASH) is a polygenic disease associated with the metabolic syndrome, however, the pathogenesis is poorly understood. The methionine-choline deficient (MCD) diet is an extensively utilized animal model for progressive steatohepatitis. Recently in silico QTL analysis has been developed as a novel method for chromosomal mapping of complex disease-related traits (1). The aims of this study are to define strain-specific differences of the MCD model of NASH and to utilize in silico mapping analysis to identify gene loci associated with steatohepatitis. Methods: A/J, AKR/J, BALB/c/J…
Schlagworte
Genomanalyse
Mausmodell
Nicht-alkoholische Steatohepatitis
Suszeptibilitätsgene
Diet
Chromosomes
Database
Choline
Affect
Zeitschrift für Gastroenterologie
