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Genetic Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) in Orthotopic Liver Transplant Recipients are Determinants for Elevated Serum Homocysteine and Vascul…

B Akoglu, P Kindl, K Wondra, N Weber, J Trojan, WF Caspary, D Faust · Zeitschrift für Gastroenterologie · 2004 · Heft 08

Dokument
1131877
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
B Akoglu, P Kindl, K Wondra, N Weber, J Trojan, WF Caspary, D Faust
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-831808

Zusammenfassung

Hyperhomocysteinemia is a known risk factor of cardiovascular diseases and is frequently associated with impaired folate metabolism. C677T polymorphism in the methyltetrahydrofolate reductase (MTHFR) gene, which is a key enzyme in folate metabolism, results in thermolability, decreased enzyme activity and hyperhomocysteinemia. MTHFR distribution in the general population is 45% for the wild type (CC), 45% for the heterozygote type (CT), and 10% for the homozygote type (TT). Liver transplant recipients have an increased cardiovascular risk because of obesity, arterial hypertension, diabetes mellitus, and hyperlip…

Schlagworte

Homocysteine MTHFR liver transplantation vascular complications Diabetes Mellitus Arteriosclerosis Population Obesity After Transplantation Zeitschrift für Gastroenterologie