Modulation of Afferent Inhibition in Healthy Subjects

Object: To investigate factors that modulate afferent inhibition (AI) in healthy subjects. Methods: AI was evoked by electrical stimuli applied over digit V of the right hand given 15, 25, 35 and 50 ms prior to transcranial magnetic stimulation (TMS) over the left M1. Motor evoked potentials (MEP) of single and double pulse TMS were recorded from the right abductor digiti minimi (ADM) and right abductor pollicis brevis (APB). We first studied the influence of contralateral voluntary preinnervation of the left hand on AI recorded from the right hand. Secondly, we studied effects of electrical stimulation (three t…