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Telomere Lagging Strand Synthesis Dysfunction in Cells Lacking WRN Helicase Activity

J Karlseder, L Crabbe, R Verdun, C Haggblom · Klinische Neurophysiologie · 2004 · Heft 08

Dokument
1131896
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
J Karlseder, L Crabbe, R Verdun, C Haggblom
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-25 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2004-832038

Zusammenfassung

Werner syndrome is an autosomal recessive disease, and individuals suffering from the syndrome show all signs of premature ageing. Cells from Werner Syndrome patients are characterized by slow growth rates, premature senescence, accelerated telomere shortening rates and genome instability. The syndrome is caused by the loss of the RecQ helicase WRN, but the underlying molecular mechanism is unclear. Here, we report that WRN localizes to telomeres in primary fibroblasts and that cells lacking WRN exhibit telomerase dependent telomere fusions. Werner syndrome cells suffer from the loss of individual telomeres duri…

Schlagworte

Syndrome Telomere Cells Telomeres Werner Lagging Strand Synthesis Dysfunction Lacking Helicase Premature Klinische Neurophysiologie