Neurofunctional Correlates and Pharmagological Modulation of Cognitive Inhibition in Major Depression: A Study with erfMRI

Introduction: Neurofunctional studies provided evidence that a dysfunctional fronto-cingulate circuit might be related to deficits of cognitive control in major depression. Altered prefrontal and ACC blood flow associated with cognitive deficits in the depressive state were described (George et al. 1997; Okada et al. 2003). Moreover, altered activation of the anterior cingulate cortex (ACC) has been reported to have a predictive power for antidepressant treatment response (Mayberg, 2003). Aside from influencing depressive mood, antidepressants appear to have a differential effect on cognitive functions. However,…