Cortical Gene Expression after Spreading Depression

Cortical spreading depression (SD) plays an important role during migraine aura and stroke. In focal cerebral ischemia, peri-infarct depolarizations (PD), a phenomenon consistent with SD in normal brain, cause expansion of the infarct size within the ischemic penumbra. Otherwise, preconditioning with SD can modulate the outcome of an ischemic injury: when SD occurs more than a day before ischemia, injury is reduced. A number of previous studies showed that gene expression changed after experimentally induced stroke. The aim of this study was to investigate the impact of SDs on the pathophysiological processes af…