Parieto-occipital atrophy in chronic juvenile ALS with long-term progression of 47 years

Background: Chronic juvenile ALS is a heterogeneous disease, characterized by age of onset before 25 years, a progressive and benign course, upper and lower motor neuron involvement and the absence of sensory, cerebellar, extrapyramidal and other atypical features. Abnormalities on magnetic resonance imaging (MRI) have been reported in the cortex and corticospinal tract of a subset of typical ALS patients. Little is known about MRI features of ALS patients with long-term progression and survival. Case Report: we report a 71 years old male patient, who at the age of 24 years developed a slowly-progressive upper a…