CareLit Fachartikel
Cystatin C is expressed in hepatic stellate cells (HSC) and upregulated during transdifferentiation to myofibroblasts (MFB)
AM Gressner, R Weiskirchen, B Lahme, S Meurer · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Dokument
1132374
CareLit-ID
Jahr
2005
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Zusammenfassung
Introduction: Cystatin C (Cys C, Cys 3, CST 3) is a low molecular weight, basic, secreted member of the cystatin superfamily of cysteine protease inhibitors, which is supposed to be involved in tissue inflammation, neutrophil chemotaxis and protection of metalloproteinases (MMPs) from autolytic degradation. Recently, Cys C was suggested as an antagonist of TGF-β (1). We studied the expression, regulation and possible TGF-β pathway interfering effect of Cys C in cultured profibrogenic rat HSC transdifferentiating to MFB. Methods: HSC were isolated from rat liver by the pronase-collagenase-method followed by densi…
Schlagworte
Hepatic Stellate Cells
Fibrose
TGF-beta
Cystatin C
Blotting
Western-
Western
Chemotaxis
Cysteine
Affect
Actin
Zeitschrift für Gastroenterologie
