The Novel Protein PTPIP51 is Upregulated in Rat Liver under Methotrexate Treatment

A novel protein sequence named protein tyrosine phosphatase interacting protein 51 (PTPIP51: SwissProt Accession code Q96SD6, EMBL accession No. HSA24271) was originally detected in a cDNA library from Jurkat cells by a yeast two hybrid approach aimed to find potential substrates of protein tyrosine phosphatases, especially PTP1B and TcPTP, by their ability to interact with these phosphatases. Tyrosine phosphatases like TcPTP and PTP1B keep the level of tyrosine phosphorylation in limits which is crucial for the regulation of cell growth, differentiation and development. The expression of the novel protein tyros…