Partial Hepatectomy Induces Mobilization of a Unique Population of Hematopoietic Progenitor Cells in Human Healthy Liver Donors
UM Gehling, M Willems, M Dandri, M Burda, J Petersen, M Berna, M Thill, T Wulf, L Müller, JM Pollok, K Schlagner, DK Hossfeld, X Rogiers · Zeitschrift für Gastroenterologie · 2005 · Heft 01
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Zusammenfassung
Abstract Recent transplantation studies in animal models and humans suggest that hematopoietic stem cells, residing in the bone marrow, can contribute to liver regeneration after injury. However, regeneration after hepatectomy is not believed to involve such cells. Here, we report that liver resection induces mobilization of hematopoietic precursor cells into the circulation. Peripheral blood samples were obtained from 11 healthy liver donors one day before and at 12 hours after classic partial hepatectomy (PH). For comparison, pre- and postoperative blood samples from patients undergoing either gynaecological o…
