CareLit Fachartikel
Analysis of a Single Nucleotide Polymorphism in the Promoter of the MxA Gene in Patients with Spontaneous and Treatment Induced Recovery from Hepatitis C Virus Infection
A Maouzi, P Wietzke-Braun, LB Mänhardt, G Ramadori, S Mihm · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Dokument
1132400
CareLit-ID
Jahr
2005
Publikation
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Interferon-α (IFN-α) is an important mediator of the hostrsquor;s innate antiviral defence system. The human recombinant protein is approved for the treatment of persistent viral infections as hepatitis B or C. However, the natural course of infection and treatment response show a great interindividual variation. This study aimed to investigate whether a functional single nucleotide polymorphism in the promoter region of the IFN-α effector MxA is associated with (a) the natural course of hepatitic C virus (HCV) infection and (b) with the outcome of an IFN-α treatment in chronic hepatitis C patients. The rare all…
Schlagworte
HCV
MxA
polymorphism
Allele
Hepatitis
Association
Zeitschrift für Gastroenterologie
