Quantification of White Matter myo-Inositol by 1H-MRS at 3.0 T in Normal Controls and in Patients with Multiple Sclerosis

Purpose: To optimize the 1H-MRS acquisition protocol for measuring absolute cerebral concentrations of myo-inositol (mIns) at 3.0 T, in order to investigate metabolic alterations in the normal appearing white matter (NAWM) of patients with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Methods: On a clinical 3.0 T whole-body MR system (Gyroscan Intera 3.0 T, Philips Medical Systems), single-voxel 1H-MRS (PRESS-localized, water suppression by dual inversion prepulses) in the parietal white matter of the centrum semiovale was performed in 10 healthy controls. Echo time was varied in th…