The inhibitory effect of Substance P on HCO3- secretion from the guinea pig microperfused pancreatic ducts
P Hegyi, Z Rakonczay Jr, T Takács, J Papp, J Lonovics, A Varró, A Tóth, M Gray, B Argent · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background. We have previously shown using sealed, non-perfused, ducts that Substance P (SP) inhibits HCO3-secretion by inhibiting Cl-dependant HCO3-efflux on the luminal membrane of the duct cell (Hegyi et al. Am J Physiol Cell Physiol 285: C268-C276, 2003). However, in that study we had no direct evidence that SP affected a luminal anion exchanger. To address this issue we examined the effects of luminal H2DIDS on the inhibitory effect of SP in microperfused ducts. Methods. Small intra/interlobular pancreatic ducts were isolated from guinea pigs. We microperfused the ducts allowing direct access to the luminal…
