CareLit Fachartikel

Alterations of proliferating cell nuclear antigen and p53 expressions in the reflux esophagitis-metaplasia-dysplasia-adenocarcinoma sequence of the esophagus

I Hritz, L Herszényi, B Molnár, Zs Tulassay · Zeitschrift für Gastroenterologie · 2005 · Heft 05

Dokument
1132785
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
I Hritz, L Herszényi, B Molnár, Zs Tulassay
Ausgabe
Heft 05 / 2005
Seiten
–
Erschienen: 2005-05-04 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-869698

Zusammenfassung

Background: Barrett esophagus predisposes individuals to esophageal carcinoma. Understanding the cellular and molecular events in the progression of Barrett esophagus to adenocarcinoma may contribute to its early diagnosis. Mutation and overexpression of the tumor suppressor p53 and increased cell proliferation have previously been observed in Barrett high-grade dysplasia and adenocarcinoma, but the role of these parameters in early stages of carcinogenesis is still controversial. Aim: To characterize expressions of proliferating cell nuclear antigen (PCNA) and p53 in the reflux esophagitis-metaplasia-dysplasia-…

Schlagworte

Adenocarcinoma Barrett Esophagus Diagnosis ANOVA Tumor Zeitschrift für Gastroenterologie