The MTL and the human entorhinal cortex synaptic currents in declarative memory – a study using fMRI and human microlaminar recordings

Aim: The human mesial temporal lobe (MTL) is involved in declarative memory. The exact contributions of MTL structures are still not understood. Using fMRI and human micro-electrode laminar recordings of the left entorhinal cortex (ER) we investigated the specific role of the MTL and the human ER in declarative memory and determined how neuronal excitation or inhibition are distributed across cortical layers in the ER during memory processes. Methods: We used rapid event-related fMRI at 3T in 18 healthy, right handed subjects. The applied paradigm allowed the comparison of activity during episodic memory encodin…