CareLit Fachartikel
Mutations in the familial Parkinson's disease gene PINK1 enhance the sensitivity to apoptosis induced by proteasomal stress
N Thurow, S Gispert, G Auburger, D Kögel · Aktuelle Neurologie · 2005 · Heft 10
Dokument
1133097
CareLit-ID
Jahr
2005
Publikation
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Zusammenfassung
Objectives: PINK1 is a putative mitochondrial protein kinase implicated in the pathophysiology of Parkinson's disease (PD). It has recently been shown that mutations in PINK1 are associated with early onset forms of PD. Since proteasome dysfunction and apoptotic cell death seem to play fundamental roles in PD and since mitochondria are crucially involved in apoptosis, we were interested whether 1) familial PINK1 mutations might sensitize cells to apoptosis induced by proteasome stress or 2) whether they might lead to a general sensitization to apoptotic stimuli. Methods: Primary fibroblasts were obtained from al…
Schlagworte
Apoptosis
Cytochrome C
Cytochrome
Germany
Lead
After
Aktuelle Neurologie
