Conditional control of human wildtype and mutated [A30P] alpha-synuclein in a mouse model of Parkinson's disease
S Nuber, T Schmidt, H.W Habbes, M Löbbecke-Schumacher, P Teismann, J.B Schulz, B.J Pichler, M Neumann, M Fendt, D Berg, C Holzmann, U Grasshoff, J Boy, I Schmitt, A Bornemann, F Zimmermann, W Kuhn, S Prusiner, E Petrasch-Parwez, O Riess · Aktuelle Neurologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Alpha-synuclein, a small soluble protein is expressed primarily at presynaptic terminals in the central nervous system. It has been implicated in the pathophysiology of many neurodegenerative disorders, including Parkinson's disease and dementia with Lewy-bodies, collectively referred to as synucleinopathies. As neurodegenerative disorders like Parkinson's disease are charecterized by progressive neuropathological and clinical symptoms, conditional models of these neurodegenerative diseases are powerful means to analyze the relationship between transgene expression and progression of the disease. We have created…
