Regulated expression of Deleted in malignant brain tumours 1 (DMBT1) in intestinal epithelial cells: a protective mucosal defense mechanism
C Sina, C End, S Hellmig, A Poustka, J Mollenhauer, UR Fölsch, S Schreiber, PC Rosenstiel · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background & Aims: Mucosal epithelial cell layers are constantly exposed to a complex resident microflora. DMBT1 (deleted in malignant brain tumors 1) belongs to the group of secreted scavenger receptor cysteine-rich (SRCR) proteins and is considered to be involved in host defense by pathogen binding. This report describes the regulation and function of DMBT1 in intestinal epithelial cells, which form the primary immunological barrier for invading pathogens. Methods: Expression of DMBT1 mRNA was determined by RT-PCR and Taqman® real time PCR, DMBT1 protein was detected by Western blot of biopsies. Promoter studi…
