Spatial Organization and Composition of the Mucosal Flora in Inflammatory Bowel Disease–A fluorescence in situ hybridization (FISH) study
A Swidsinski · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Bopsies from patients with IBD and controls, whole intestines for normal mice and for three models of murine colitis were investigated using FISH. Results: No adherent biofilms were present in the intestine of healthy controls. In contrast, a dense tightly adherent biofilm was detected in all IBD patients. Less abundant biofilm was also found in 60% of patients with IBS. The composition of biofilm in controls and IBD differed. Bacteroides spp. were predominant in IBD, while Eubacterium rectale was predominant in IBS. In some IBD patients, specific biofilms with mainly E.coli or Serpulina were observed. Sim…