Pleiotrophin/Heparin affin regulatory peptide (HARP) in cultured rat hepatic stellate cells is upregulated under hypoxia and PDGF stimulation: Implication for the early phase of l…
M Antoine, CG Tag, W Wirz, M Mavituna, I Sawitza, AM Gressner, R Müller, P Kiefer · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Pleiotrophin (PTN) is a secretory heparin binding protein with various biological activities including mitogenesis, angiogenesis, differentiation, transformation, and cell survival. Employing a rat cell culture model of hepatic stellate cells (HSC) transdifferentiation, we found that PTN transcription is rapidly down-regulated in activated HSCs and in fully transdifferentiated myofibroblasts (MFB). However, release of intracellular PTN into the cell culture supernatant was highest in 3 days old activated HSC cultures. Since evidence from the bile duct ligation model of fibrosis indicates that sinusoidal HSC also…
