TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
E Schulze Schleithoff, AE Sayan, AF Koch, C Pieper, O Gressner, G Melino, PH Krammer, A Tannapfel, W Stremmel, M Müller · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
p73, a p53 family protein, has significant homology to p53. Unlike p53, the expression of p73 is regulated by two different promoters resulting in proteins with opposite functions: the full-length transcriptionally active TAp73 and the dominant negative p73 (ΔNp73). We investigated the downstream mechanisms by which TAp73ß and ΔNp73 regulate apoptosis. TAp73ß transactivated the CD95 gene via the p53-binding site in the first intron. In addition, TAp73ß induced expression of pro-apoptotic Bcl–2 family members and led to apoptosis via the mitochondrial pathway. Furthermore, endogenous p73 was upregulated in respon…
