CareLit Fachartikel
IKK1 promotes G1 phase progression of pancreatic cancer cells by the transcriptional regulation of the F-box protein skp2
G Schneider, D Saur, J Siveke, R Fritsch, RM Schmid · Zeitschrift für Gastroenterologie · 2006 · Heft 04
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1133177
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2006
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Zusammenfassung
Pancreatic cancer is one of the most lethal human cancers. Advances in cancer biology have improved the understanding of the pathogenesis of pancreatic cancer, but the diseases prognosis, with a five year overall survival below 5% is any longer extreme poor. The IKK consist of the catalytical subunits IKK1 and IKK2 and the structural subunit Nemo. This kinase is constitutive active in pancreatic cancer cells and regulates proliferative and anti-apoptotic programs. The functions of the individual catalytical subunits in pancreatic cancer cells are so far unknown. Functional genomics using RNA interference was use…
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Apoptosis
Cyclin D1
Biology
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Zeitschrift für Gastroenterologie
