Chemotherapy in advanced gastric cancer: what is the evidence?

Background: Systemic chemotherapy is the major treatment option for the majority of gastric cancer patients. Uncertainty remains regarding the choice of the regimen Objectives: To assess the effect of 1. Chemotherapy versus best supportive care (BSC), 2. Combination versus single agent chemotherapy 3. The following different combination chemotherapy regimens: a.) 5-FU/cisplatin combinations with versus without anthracyclines b.) 5-FU/anthracycline combinations with versus without anthracyclines Search strategy: We searched: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, proceedings from DDW, EC…