CareLit Fachartikel
Mcl–1 Promotes Drug Resistance in Pancreatic Cancer Cells
R Fritsch, G Schneider, D Saur, RM Schmid · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
1133180
CareLit-ID
Jahr
2006
Publikation
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Metadaten
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Zusammenfassung
Due to the lack of effective therapy, pancreatic adenocarcinoma is unalteredly causing every fifth cancer–related death in the western world. On the cellular level, resistance to conventional chemotherapy is reflected by a pronounced apoptosis resistance of pancreatic cancer cells. In search of stimuli overcoming apoptosis resistance in pancreatic cancer, we found that UV-irradiation rapidly induced apoptosis in all of 11 pancreatic cancer cell lines (n=11) tested. UV-induced apoptosis occurred rapidly, was dose-dependent and did not require ongoing protein synthesis. Activation of Bax and release of cytochrom c…
Schlagworte
Apoptosis
Drug Resistance
Adenocarcinoma
Caspases
Affect
Tumor
Zeitschrift für Gastroenterologie
