Modulation of Stress- and Inflammation induced Visceral Hypersensitivity by peripheral Neurokinin 1 Receptors

Aims: Altered processing of visceral afferent information is believed to play a key role for the manifestation of symptoms in patients with functional gastrointestinal disorders. While it is well recognized that initiating events such as mucosal inflammation and stress precipitate the onset of symptoms the underlying mechanisms are poorly understood. Tachykinins and their receptors are known to modulate gastrointestinal function including motility, visceral sensitivity and inflammation. Aims: We aimed to study (1) the effect of mucosal inflammation, (2) a repeated standardized stressor and (3) the role of Neurok…