CareLit Fachartikel
Gene expression profiling predicts response of rectal adenocarcinomas to neoadjuvant radiochemotherapy
BM Ghadimi, M Grade, T Liersch, T Ried, H Becker · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Dokument
1133201
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Jahr
2006
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Zusammenfassung
When preceding surgery, neoadjuvant radiochemotherapy can decrease local recurrence and has become standard treatment modality in specialized surgical centers. However, there is a wide spectrum of tumor responsiveness ranging from complete response to complete resistance. Pre-therapeutic predictors would therefore be of considerable clinical significance for stratification of patients into groups of responders or non-responders of radiochemotherapy. Pre-therapeutic biopsies from 23 locally advanced rectal carcinomas (determined by rectal ultrasound as uT3 and uT4) were analyzed for gene expression signatures usi…
Schlagworte
Computertomographie
Diagnostik
After
Chemotherapie
Tumor
Zeitschrift für Gastroenterologie
