Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer

Objective: Differential methylation of cancer associated genes plays a pivotal role in tumor development. Several studies using candidate gene analyses or genome wide approaches suggest that these alterations occur in a non-random fashion and affect genes with various function in all cancer entities. The purpose of this study was to identify novel genes affected by de novo methylation in breast carcinomas. Materials and Methods: Therefore, we compared the methylation status of 7680 CpG-rich fragments of the human genome in 10 primary breast carcinomas (BrCa) and corresponding normal tissues (NT) by CpG island mi…