Level differentials of proteolytic factors uPA, PAI-1 and human kallikreins (hK) 5,6,7,8,10,11,13 in primary ovarian carcinoma tissues and corresponding omentum metastases impact…
J Dorn, M Schmitt, RE Kates, A Scorilas, L Grass, A Soosaipillai, EP Diamandis, M Kiechle, B Schmalfeldt, N Harbeck · Zentralblatt für Gynäkologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Proteolytic factors of the plasminogen activation system and human tissue kallikreins hK4–15 are involved in tumor progression in ovarian cancer. 142 primary ovarian cancer patients FIGO I-IV were operated on at Dept OB&GYN, TU Munich (median follow-up 33 months). Antigen levels of uPA, PAI-1 and 7 tissue kallikreins (hK5,6,7,8,10,11,13) were determined in primary carcinoma and corresponding omentum metastasis and related to total protein content. Level in metastases minus level in primary tumor tissue was defined as level differential. Significant increases in metastasis levels compared to primary tumor levels…
