Epidermal Fatty Acid-Binding Protein (E-FABP) is increased in rat lungs following in vivo treatment with Keratinocyte Growth Factor (KGF)

Exogenous application of Keratinocyte Growth Factor (KGF) protects the lung against a variety of injurious stimuli. KGF-treatment leads to pronounced hyperplasia of alveolar epithelial type II cells and to stabilization of surfactant homeostasis after lung injury. Epidermal Fatty Acid-Binding Protein (E-FABP) is involved in the synthesis of surfactant phospholipids and acts as an antioxidant scavenging reactive lipids. Adult rats were treated twice (day 1 and 2) with recombinant human KGF (Palifermin) via intratracheal instillation (5 mg rHuKGF per kg body weight) or with an equivalent volume of PBS (200–270µl).…