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Regulation of TGF-β effects in hepatocytes by endocytosis

P Godoy, K Breitkopf, L Ciuclan, E Wiercinska, L Brusch, S Dooley · Zeitschrift für Gastroenterologie · 2006 · Heft 01

Dokument
1133483
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
P Godoy, K Breitkopf, L Ciuclan, E Wiercinska, L Brusch, S Dooley
Ausgabe
Heft 01 / 2006
Seiten
–
Erschienen: 2006-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-931638

Zusammenfassung

TGF-β is a major cytokine involved in several aspects of liver physiology (fibrosis, regeneration, apoptosis, cancer). Hepatocytes are one of the main targets of this cytokine, with apoptosis and growth inhibition seeming to be the main outcomes. Recently an important role of endocytosis in the regulation of several signaling pathways has been demonstrated, like the EGF-R/MAPK, where different routes of signal transduction triggered at miscellaneous stages of receptor endocytosis. We addressed the importance of endocytosis in the regulation of TGF-β signaling in cell lines (Hepatoma 1–6, Hep3B) and primary mouse…

Schlagworte

Endocytosis TGF-beta hepatocytes signal transduction Apoptosis Cytokine Zeitschrift für Gastroenterologie