VEGF enhances liver regeneration after partial hepatectomy
M Bockhorn, P Grünewald, P Grünewald, P Dammann, M Trippler, M Trippler, A Frilling, C Broelsch, JF Schlaak · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Although Vascular Endothelial Growth Factor (VEGF) has been shown to play a role in liver tissue repair, the underlying mechanisms are unknown. Aims of the study were to determine the effects of exogenous and endogenous VEGF after partial hepatectomy (PH) in a rat model. Methods: Lewis rats were subjected to 70% PH and split into 3 groups. Group A (VEGF), group B (anti-VEGF), and group C (Control). Postoperatively, vessel density (VD), vessel diameter (VDi) and intervascular space (iVS), liver body weight ratio (LBR) and Ki–67 immunostaining in 5 rats per time point and group were recorded (n=120). Express…
