Kinetic Modelling of the Input/Output Dynamics of a Perfused 3D Multi-Compartment Capillary Membrane Bioreactor for Extracorporeal Liver Support

The provision of standardised bioreactor technology for liver cell research and liver support therapy requires along the devices’ design a quantitative characterisation of their dynamic input/output behaviour under operation. Characterisation of abiotic prior to biotic behaviour is here an essential step served by studies on the distribution of model substances in the systems. We report here on the kinetic modelling of the input/output dynamics of a clinical scale perfused 3D multi-compartment capillary membrane bioreactor based on NaCl tracer experiments. The experimental set-up consisted of the bioreactor and…