Treatment of chronic hepatitis delta with pegylated interferon-alfa2b – a pilot study
A Erhardt, W Gerlich, C Starke, U Wend, A Donner, A Sagir, T Heintges, D Häussinger · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: So far there is no effective treatment of chronic hepatitis D. The present pilot study addressed the question whether pegylated interferon-alfa2b is effective in chronic hepatitis D. Patients and methods: Twelve patients with chronic hepatitis D were prospectively treated with 1.5µg/kg pegylated interferon-alfa2b for 48 weeks and followed for another 24 weeks. Sustained response (SR) was defined as undetectable HDV-RNA (by RT-PCR) and normalization of ALT at 6 months after treatment. Study investigations included HDV RNA kinetics, determination of HBV and HDV genotypes and histological evalu…
