Variants and Differential Diagnosis of Peripheral Nerve Hyperexcitability
HJ Gdynia, AC Ludolph, AD Sperfeld · Klinische Neurophysiologie · 2006 · Heft 03
Bibliografische Angaben
Zusammenfassung
Aims: Peripheral nerve hyperexcitability syndromes (PNHS) are a heterogeneous group of diseases characterized by spontaneous muscle fiber activity, e.g. myokymias and fasciculations. Acquired, hereditary and idiopathic forms are known. Antibodies to voltage-gated potassium channels (VGKCs) appear likely to be the main effector mechanism in many patients with acquired PNHS. Neuromyotonia (Isaacs' syndrome when acquired), cramp-fasciculation syndrome and Morvan's disease are phenotypic variants of PNHS. Beside of idiopathic forms the association of PNHS and autoimmune diseases is well known. Furthermore medication…