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Dantrolene protects motoneurons in culture against AMPA receptor mediated excitotoxicity

K Haastert, K Jahn, R Dengler, C Grothe, J Bufler, J Grosskreutz · Klinische Neurophysiologie · 2006 · Heft 03

Dokument
1133636
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
K Haastert, K Jahn, R Dengler, C Grothe, J Bufler, J Grosskreutz
Ausgabe
Heft 03 / 2006
Seiten
–
Erschienen: 2006-03-24 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2006-939158

Zusammenfassung

Chronic excitotoxicity induced by overstimulation of calcium permeable AMPA receptors (AMPAR) was shown to be a key factor in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). The presence of AMPAR, however, is also necessary for neuronal development. AMPAR may exert such bimodal influence on neuronal survival by altering intracellular calcium homeostasis through control of calcium induced calcium release from the endoplasmic reticulum (ER). The objective of this investigation was to determine a protective effect of the selective ryanodine receptor blocker dantrolene against AMPA/Kainate-induced excitotox…

Schlagworte

Calcium Dantrolene AMPA Antibodies Amyotrophic Lateral Sclerosis Klinische Neurophysiologie