The breakdown of glutamate clearance plays a major role in the pathogenesis of SIV encephalitis
E Neuen-Jacob, D Vosswinkel, S Sopper, F Meisner, C Scheller, J Müller, P Riederer, V ter Meulen, E Koutsilieri · Aktuelle Neurologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Introduction: Clinical, neuroimaging and experimental data in SIV-infected macaques strongly suggest that basal ganglia dysfunction plays an important role in the pathogenesis of HIV encephalitis (HIVE). The regulation of glutamatergic neurotransmission in inflammation is a complex interaction between activation of immune mediators and adaptative changes of the functional elements of the glutamatergic synapse. Since glutamate is abundant in the brain and potentially toxic to neurons expressing NMDA receptors, protective mechanisms are required to prevent glutamate excitoxicity. The aim of our study in the SIV mo…
