CareLit Fachartikel
Analysis of co-morbidities in a database of ALS patients
J Ilsemann, K Kollewe, R Dengler, K Krampfl, S Petri · Aktuelle Neurologie · 2008 · Heft 09
Dokument
1133799
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disorder with an average survival of 3–5 years after the onset of symptoms. It is characterized by a rapidly progressive loss of upper motor neurons in the primary motor cortex and lower motor neurons in brainstem and spinal cord. A defined genetic defect (mutations in the Superoxide Dismutase (SOD) 1 gene) is detected in about 20 percent of familial cases. Most ALS-cases, however, occur sporadically. Many different pathomechanisms such as excitotoxicity, oxidative stress, disruption of axonal transport, lack of neurotrophic factors…
Schlagworte
Population
Database
Amyotrophic Lateral Sclerosis
Movement Disorders
Axonal Transport
Outpatients
Depression
Movement
Anxiety
After
Aktuelle Neurologie
