Effects of ezetimibe on LDL receptor- and HMG-CoA reductase-gene expression, on LDL receptor protein expression and on HMG-CoA reductase activity in mononuclear blood cells of hea…
I Berthold, Y Ko, S Stier, E Giannakidou, H Gylling, J Plat, HK Berthold, W Krone · Diabetologie und Stoffwechsel · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Purpose of the study: Achieving target LDL-cholesterol (LDL-C) levels is of utmost importance, especially in patients with diabetes mellitus. The combination of simvastatin and the cholesterol absorption inhibitor ezetimibe is widely used to attain this goal. Purpose of the present study was to examine the effects of these agents and their combination on LDL-receptor- (LDLR) and HMG-CoA reductase-gene expression, on the LDLR protein expression and on the HMG-CoA reductase activity in peripheral blood mononuclear cells (PBMC). Methods: The study is a prospective, randomized, parallel 3-group trial. Three groups o…
