HBV specific adoptive immune transfer by living liver donation
A Schumann, M Lindemann, C Valentin-Gamazo, CE Broelsch, H Grosse-Wilde, M Roggendorf, M Fiedler · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Liver transplantation is often the ultimate option of therapy for chronically hepatitis B virus (HBV) infected patients. Despite antiviral therapy reinfection is still a problem. Adoptive transfer of HBV immunity with the liver after vaccination of living liver donors (LLDs) could be a new approach to prevent reinfection in the recipients. The time to achieve HBV immunity in LLDs is usually short (1–2 months). Therefore, we established a short time immunization protocol (4 injections in two weeks intervals) using Hepimmune (Berna Biotech), a recombinant vaccine that contains the PreS1, PreS2, and S proteins of H…
