CareLit Fachartikel

Evaluation of soluble CD44 variants (std, v5 and v6) in patients with primary breast cancer

S Mayer, DC Fischer, D Watermann, M Jäger, G Gitsch, E Stickeler · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09

Dokument
1134323
CareLit-ID
Jahr
2006
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
S Mayer, DC Fischer, D Watermann, M Jäger, G Gitsch, E Stickeler
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0016-5751
DOI
10.1055/s-2006-952508

Zusammenfassung

Introduction: CD44 is a transmembrane adhesion molecule involved in cell-cell and cell-substrate interactions. As a cell surface glycoprotein, CD44 may be shed or released into circulation by proteolytic enzymatic mechanisms. Alternative splicing of CD44 and aberrant levels of soluble CD44 protein in the serum of cancer patients has been correlated to tumor progression and metastasis. In this study we evaluated the clinical value of CD44 serum levels (sCD44) in patients with primary (non metastatic) breast cancer. Material and Methods: Concentrations of the soluble, variable isoforms sCD44std, sCD44v5 and sCD44v…

Schlagworte

Breast Tumor Alternative Splicing Blood Donors Blood Geburtshilfe und Frauenheilkunde