Selective affection of hippocampal CA -1 neurones in patients with transient global amnesia – a prospective clinical and 3 T MRI study

The anatomy, etiology and pathomechanisms of transient global amnesia (TGA) still remain obscure. Several etiological factors such as migraine, focal ischemia, venous flow abnormalities and epileptic phenomena have been suggested to be involved in the pathophysiology. Recently, transient DWI lesions in the hippocampus have been described in patients with TGA, but the exact distribution and long term outcome of these lesions still remain unknown. Here, the topography and time course of hippocampal DWI lesions in 39 TGA patients was studied using serial 3 T high-resolution MR-imaging. Twenty seven patients showed…